Enhancement of the protective efficacy of anoprFDNA vaccine againstPseudomonas aeruginosa

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Enhancement of the protective efficacy of an oprF DNA vaccine against Pseudomonas aeruginosa.

The outer membrane protein F gene (oprF) of Pseudomonas aeruginosa was recently shown by us to protect mice from P. aeruginosa chronic pulmonary infection when used as a DNA vaccine administered by three biolistic (gene gun) intradermal inoculations given at 2-week intervals. In the present study, we used two different strategies to improve the protective efficacy of the DNA vaccine. In the fir...

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ژورنال

عنوان ژورنال: FEMS Immunology & Medical Microbiology

سال: 2002

ISSN: 0928-8244,1574-695X

DOI: 10.1111/j.1574-695x.2002.tb00577.x